Exercise:
It was suggested that long-acting calcium blockers have a higher risk for coronary artery disease compared to other types of anti-hypertensive agents. Thus, a literature search was performed to select randomized clinical trials (RCTs) for the long-acting calcium blockers and other anti-hypertensive agents (diuretics, β-blockers, and ACE inhibitors). The selected RCTs except one included 100 and more participating patients with 2 years and more follow-up period. The following are the comparison data of myocardial infarction as the event. Combine these trials and perform the meta-analysis. (Egger M & Smith GD, Bias in location and selection of studies. BMJ, 316: 61-66, 1998. )
